Knowledge base

After multiple events of patient samples not being managed in an optimal fashion, guidelines were published in 2020 and updated in 2023 regarding fixation of breast tissue samples tested for ER/PR/Her2 expression. 

Histology has been processing tissue in essentially the same way for decades. It's a technique that works so well that it has little changed over time.

For a while now, histology laboratories have standardized tissue fixation using 10% neutral buffered formaldehyde. Proper fixation is essential because all the following laboratory procedures rely on adequate fixation to render quality results possible.